ABSTRACT
A infecçäo por Capilária hepática é rara em humanos sendo, a maioria dos casos, diagnosticados à autópsia. Os autores relatam um caso de diagnóstico histopatológico em um menino de 17 meses; apresentam sua evoluçäo clínico-laboratorial e destacam o sucesso obtido com a terapêutica empregada
Subject(s)
Infant , Humans , Male , Nematode Infections/pathology , Capillaria , Follow-Up Studies , Nematode Infections/drug therapy , Nitrophenols/therapeutic use , Prednisone/therapeutic use , Pyrantel Tartrate/therapeutic useABSTRACT
A clinical trial of Niclofolan on human opisthorchiasis was carried out in 60 patients admitted to the Hospital for Tropical Diseases. Two dosage regimen, 2 mg and 3 mg per kg body weight repeated after a 72 hour interval was administered to 31 and 4 patients respectively. Comparative evaluation with the placebo group of 25 patients was made by the Stoll count on day 20, 40 and 60 after treatment. On day 60 percentage egg reduction of the treated and the placebo groups were similar. Mild and transient side effects such as nausea, anorexia, myalgia and arthralgia were recorded in all 3 groups but more severe in the higher dosage group. In this study, Niclofolan failed in reducing the egg production of Opisthorchis viverrini.
Subject(s)
Adolescent , Clinical Trials as Topic , Female , Humans , Male , Niclofolan/adverse effects , Nitrophenols/therapeutic use , Opisthorchiasis/drug therapy , Parasite Egg Count , ThailandABSTRACT
Twelve doses of Ancylol Disophenol at 0.05 ml per pound body weight administered subcutaneously was shown to be an effective chemotherapeutic agent against migrating stage of G. spinigerum in cats. A further investigation is required to determine whether this regimen is the minimum effective therapeutic dosage. None of eight cats treated with 12 doses of 0.02 to 0.05 ml per pound body weight showed signs or symptoms of toxicity due to the treatment and there were not gross pathological changes of the organs observed on necropsy of the animals.